PUBLICATIONS

2025

Cell-type-informed genotyping of mosaic focal epilepsies reveals cell-autonomous and non-cell-autonomous disease-associated transcriptional programs

Sara Bizzotto, Maya Talukdar, Edward A. Stronge, Rosita B. Ramirez, Yingxi Yang, …, Russell J. Buono, Ingmar Blümcke, Annapurna H. Poduri, Sattar Khoshkhoo, Christopher A. Walsh

Proceedings of the National Academy of Sciences · 17 Jul 2025 · doi:10.1073/pnas.2509622122

Clonal Hematopoiesis Mutations Increase Risk of Alzheimer’s Disease with APOE ε3/ε3 Genotype

Jaejoon Choi, Kyung Sun Park, Yann Le Guen, Jong-Ho Park, Zinan Zhou, …, Yoon-Ho Choi, Christopher A. Walsh, Jong-Won Kim, August Yue Huang, Eunjung Alice Lee

bioRxiv · 21 May 2025 · doi:10.1101/2025.05.19.654981

Advances in single-cell DNA sequencing enable insights into human somatic mosaicism

Diane D. Shao, Andrea J. Kriz, Daniel A. Snellings, Zinan Zhou, Yifan Zhao, Liz Enyenihi, Christopher Walsh

Nature Reviews Genetics · 25 Apr 2025 · doi:10.1038/s41576-025-00832-3

Recurrent patterns of widespread neuronal genomic damage shared by major neurodegenerative disorders

Zinan Zhou, Lovelace J. Luquette, Guanlan Dong, Junho Kim, Jayoung Ku, …, Andre Nussenzweig, Peter J. Park, Clotilde Lagier-Tourenne, Eunjung Alice Lee, Christopher A. Walsh

bioRxiv · 05 Mar 2025 · doi:10.1101/2025.03.03.641186

2024

Neuropathologically directed profiling of PRNP somatic and germline variants in sporadic human prion disease

Gannon A. McDonough, Yuchen Cheng, Katherine S. Morillo, Ryan N. Doan, Zinan Zhou, …, Brian S. Appleby, Christopher A. Walsh, Jiri G. Safar, August Yue Huang, Michael B. Miller

Acta Neuropathologica · 24 Jul 2024 · doi:10.1007/s00401-024-02774-2

Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes

Javier Ganz, Lovelace J. Luquette, Sara Bizzotto, Michael B. Miller, Zinan Zhou, …, Yasmine Chahine, Brian Chhouk, Alon Galor, Peter J. Park, Christopher A. Walsh

Cell · 01 Apr 2024 · doi:10.1016/j.cell.2024.02.025

Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microglia

August Yue Huang, Zinan Zhou, Maya Talukdar, Michael B. Miller, Brian Chhouk, …, Ed Lein, Philip L. De Jager, David A. Bennett, Eunjung Alice Lee, Christopher A. Walsh

bioRxiv · 04 Jan 2024 · doi:10.1101/2024.01.03.574078

2023

Somatic Mosaicism in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Reveals Widespread Degeneration from Focal Mutations

Zinan Zhou, Junho Kim, August Yue Huang, Matthew Nolan, Junseok Park, …, Olaf Ansorge, Lyle W. Ostrow, Clotilde Lagier-Tourenne, Eunjung Alice Lee, Christopher A. Walsh

bioRxiv · 01 Dec 2023 · doi:10.1101/2023.11.30.569436

2022

Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements

Lovelace J. Luquette, Michael B. Miller, Zinan Zhou, Craig L. Bohrson, Yifan Zhao, …, Juan I. Garaycoechea, Charles Gawad, Jay West, Christopher A. Walsh, Peter J. Park

Nature Genetics · 26 Sep 2022 · doi:10.1038/s41588-022-01180-2

Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity

Sangita Choudhury, August Yue Huang, Junho Kim, Zinan Zhou, Katherine Morillo, …, Sarah Araten, Nazia Hilal, Eunjung Alice Lee, Ming Hui Chen, Christopher A. Walsh

Nature Aging · 11 Aug 2022 · doi:10.1038/s43587-022-00261-5

Somatic genomic changes in single Alzheimer’s disease neurons

Michael B. Miller, August Yue Huang, Junho Kim, Zinan Zhou, Samantha L. Kirkham, …, Matthew P. Frosch, Bradley T. Hyman, Michael A. Lodato, Eunjung Alice Lee, Christopher A. Walsh

Nature · 20 Apr 2022 · doi:10.1038/s41586-022-04640-1

2021

Rates and Patterns of Clonal Oncogenic Mutations in the Normal Human Brain

Javier Ganz, Eduardo A. Maury, Basheer Becerra, Sara Bizzotto, Ryan N. Doan, …, Junho Kim, Zinan Zhou, Keith L. Ligon, Eunjung Alice Lee, Christopher A. Walsh

Cancer Discovery · 13 Aug 2021 · doi:10.1158/2159-8290.cd-21-0245

2016

Label-free fluorimetric detection of CEA using carbon dots derived from tomato juice

Hong Miao, Lan Wang, Yan Zhuo, Zinan Zhou, Xiaoming Yang

Biosensors and Bioelectronics · 01 Dec 2016 · doi:10.1016/j.bios.2016.06.043

Micro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient Mice

Jaesung P. Choi, Matthew Foley, Zinan Zhou, Weng-Yew Wong, Naveena Gokoolparsadh, J. Simon C. Arthur, Dean Y. Li, Xiangjian Zheng

PLOS ONE · 11 Aug 2016 · doi:10.1371/journal.pone.0160833

Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling

Zinan Zhou, Alan T. Tang, Weng-Yew Wong, Sharika Bamezai, Lauren M. Goddard, …, Kevin J. Whitehead, Issam A. Awad, Dean Y. Li, Xiangjian Zheng, Mark L. Kahn

Nature · 30 Mar 2016 · doi:10.1038/nature17178

2015

The Cerebral Cavernous Malformation Pathway Controls Cardiac Development via Regulation of Endocardial MEKK3 Signaling and KLF Expression

Zinan Zhou, David R. Rawnsley, Lauren M. Goddard, Wei Pan, Xing-Jun Cao, …, Dean Li, Bin Zhou, Benjamin A. Garcia, Xiangjian Zheng, Mark L. Kahn

Developmental Cell · 01 Jan 2015 · doi:10.1016/j.devcel.2014.12.009

Papain-templated Cu nanoclusters: assaying and exhibiting dramatic antibacterial activity cooperating with H₂O₂

Hong Miao, Dan Zhong, Zinan Zhou, Xiaoming Yang

Nanoscale · 01 Jan 2015 · doi:10.1039/c5nr05362e

2014

Stable isotope dilution liquid chromatography/mass spectrometry analysis of cellular and tissue medium‐ and long‐chain acyl‐coenzyme A thioesters

Nathaniel W. Snyder, Sankha S. Basu, Zinan Zhou, Andrew J. Worth, Ian A. Blair

Rapid Communications in Mass Spectrometry · 09 Jul 2014 · doi:10.1002/rcm.6958

2009

Plk1-mediated Phosphorylation of Topors Regulates p53 Stability

Xiaoming Yang, Hongchang Li, Zinan Zhou, Wen-Horng Wang, Anping Deng, Ourania Andrisani, Xiaoqi Liu

Journal of Biological Chemistry · 01 Jul 2009 · doi:10.1074/jbc.c109.001560