I received my Ph.D. from Fudan University in the laboratory of Dr. Jinchuan Hu, where I studied DNA damage and repair mechanisms using genome-wide sequencing approaches, with a particular focus on transcription-coupled nucleotide excision repair. During my doctoral training, I developed and applied Protein-Associated DNA Damage Sequencing (PADD-seq), a genome-wide approach for mapping protein-DNA damage interactions, to investigate how lesion-stalled RNA polymerase II is resolved during transcription-coupled repair.

Before joining the Zhou Laboratory, I conducted postdoctoral research in the laboratory of Dr. Dong Wang at the University of California, San Diego, where I developed a sequencing-based approach to profile metabolically derived DNA damage and repair dynamics across the human genome.

In the Zhou Laboratory, I am interested in understanding how DNA damage and repair processes shape somatic mutagenesis and cellular vulnerability in the aging human brain. My current focus is on applying sequencing-based and computational approaches to study somatic mutations and related genomic changes in neurodegenerative disease.